Anders, S., Pyl, P.T. & Huber, W. 2015. HTSeq - a Python framework to work with high-throughput sequencing data. Bioinformatics 31(2): 166-169.

Anusewicz, D., Orzechowska, M. & Bednarek, A.K. 2020. Lung squamous cell carcinoma and lung adenocarcinoma differential gene expression regulation through pathways of Notch, Hedgehog, Wnt, and ErbB signalling. Scientific Reports 10(1): 21128.

Ardi, V.C., Deryugina, E.I. & Quigley, J.P. 2020. Neutrophil elastase facilitates cancer cell motility via induction of Akt signaling pathway. The FASEB Journal 34(S1): 1-1.

Ashrafi, A., Akter, Z., Modareszadeh, P., Modareszadeh, P., Berisha, E., Alemi, P.S., Chacon Castro, M.D.C., Deese, A.R. & Zhang, L. 2022. Current landscape of therapeutic resistance in lung cancer and promising strategies to overcome resistance. Cancers 14(19): 4562.

Bhargav, A., Bhalla, N., Manoharan, S., Singh, G., Yadav, S.K. & Singh, A.K. 2023. Role of various immune cells in the tumor microenvironment. Diseases & Research 3(1): 30-40.

Bordeleau, F., Mason, B.N., Lollis, E.M., Mazzola, M., Zanotelli, M.R., Somasegar, S., Califano, J.P., Montague, C., LaValley, D.J., Huynh, J., Mencia-Trinchant, N., Negrón Abril, Y.L., Hassane, D.C., Bonassar, L.J., Butcher, J.T., Weiss, R.S. & Reinhart-King, C.A. 2017. Matrix stiffening promotes a tumor vasculature phenotype. Proceedings of the National Academy of Sciences of the United States of America 114(3): 492-497.

Cai, F., Miao, Y., Liu, C., Wu, T., Shen, S., Su, X. & Shi, Y. 2018. Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer. Oncology Letters 15(1): 731-740.

Cancer Genome Atlas Research Network. 2012. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489(7417): 519-525.

Castellano, B.M., Thelen, A.M., Moldavski, O., Feltes, M., Van Der Welle, R.E.N., Mydock-McGrane, L., Jiang, X., van Eijkeren, R.J., Davis, O.B., Louie, S.M., Perera, R.M., Covey, D.F., Nomura, D.K., Ory, D.S. & Zoncu, R. 2017. Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex. Science 355(6331): 1306-1311.

Cau, F., Fanni, D., Manchia, M., Gerosa, C., Piras, M., Murru, R., Paribello, P., Congiu, T., Coni, P., Pichiri, G., Piludu, M., Van Eyken, P., Gibo, Y., La Nasa, G., Orrù, G., Scano, A., Coghe, F., Saba, L., Castagnola, M. & Faa, G. 2022. Expression of L1 cell adhesion molecule (L1CAM) in extracellular vesicles in the human spinal cord during development. European Review for Medical and Pharmacological Sciences 26(17): 6273-6282.

Cheng, H., Shcherba, M., Pendurti, G., Liang, Y., Piperdi, B. & Perez-Soler, R. 2014. Targeting the PI3K/AKT/mTOR pathway: Potential for lung cancer treatment. Lung Cancer Management 3(1): 67-75.

Choi, Y., Sims, G.E., Murphy, S., Miller, J.R. & Chan, A.P. 2012. Predicting the functional effect of amino acid substitutions and indels. PLoS ONE 7(10): e46688.

Christensen, E.M., Patel, S.M., Korasick, D.A., Campbell, A.C., Krause, K.L., Becker, D.F. & Tanner, J.J. 2017. Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. Journal of Biological Chemistry 292(17): 7233-7243.

Coradini, D., Ambrogi, F. & Infante, G. 2023. Cholesterol de novo biosynthesis in paired samples of breast cancer and adjacent histologically normal tissue: Association with proliferation index, tumor grade, and recurrence-free survival. Archives of Breast Cancer 10(2): 187-199.

Dennis, K.L., Blatner, N.R., Gounari, F. & Khazaie, K. 2013. Current status of IL-10 and regulatory T-cells in cancer. Current Opinion in Oncology 25(6): 637.

Ding, L., Getz, G., Wheeler, D.A., Mardis, E.R., McLellan, M.D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D.M., Morgan, M.B., Fulton, L., Fulton, R.S., Zhang, Q., Wendl, M.C., Lawrence, M.S., Larson, D.E., Chen, K., Dooling, D.J., Sabo, A., Hawes, A.C., Shen, H., Jhangiani, S.N., Lewis, L.R., Hall, O., Zhu, Y., Mathew, T., Ren, Y., Yao, J., Scherer, S.E., Clerc, K., Metcalf, G.A., Ng, B., Milosavljevic, A., Gonzalez-Garay, M.L., Osborne, J.R., Meyer, R., Shi, X., Tang, Y., Koboldt, D.C., Lin, L., Abbott, R., Miner, T.L., Pohl, C., Fewell, G., Haipek, C., Schmidt, H., Dunford-Shore, B.H., Kraja, A., Crosby, S.D., Sawyer, C.S., Vickery, T., Sander, S., Robinson, J., Winckler, W., Baldwin, J., Chirieac, L.R., Dutt, A., Fennell, T., Hanna, M., Johnson, B.E., Onofrio, R.C., Thomas, R.K., Tonon, G., Weir, B.A., Zhao, X., Ziaugra, L., Zody, M.C., Giordano, T., Orringer, M.B., Roth, J.A., Spitz, M.R., Wistuba, I.I., Ozenberger, B., Good, P.J., Chang, A.C., Beer, D.G., Watson, M.A., Ladanyi, M., Broderick, S., Yoshizawa, A., Travis, W.D., Pao, W., Province, M.A., Weinstock, G.M., Varmus, H.E., Gabriel, S.B., Lander, E.S., Gibbs, R.A., Meyerson, M. & Wilson, R.K. 2008. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455(7216): 1069-1075.

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M. & Gingeras, T.R. 2013. STAR: Ultrafast universal RNA-seq aligner. Bioinformatics 29(1): 15-21.

Dou, X., Menkari, C., Mitsuyama, R., Foroud, T., Wetherill, L., Hammond, P., Suttie, M., Chen, X., Chen, S.Y., Charness, M.E. & Collaborative Initiative on Fetal Alcohol Spectrum Disorders. 2018. L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. The FASEB Journal 32(3): 1364-1374.

Dwyer-Nield, L.D., McArthur, D.G., Tennis, M.A., Merrick, D.T. & Keith, R.L. 2021. An improved murine premalignant squamous cell model: Tobacco smoke exposure augments NTCU-induced murine airway dysplasia. Cancer Prevention Research 14(3): 307-312.

Emmons, T. R., Giridharan, T., Singel, K. L., Khan, A. N. M. N. H., Ricciuti, J., Howard, K., Silva-Del Toro, S.L., Debreceni, I.L., Aarts, C.E.M., Brouwer, M.C., Suzuki, S., Kuijpers, T.W., Jongerius, I., Allen, L.H., Ferreira, V.P., Schubart, A., Sellner, H., Eder, J., Holland, S.M., Ram, S., Lederer, J.A., Eng, K.H., Moysich, K.B., Odunsi, K., Yaffe, M.B., Zsiros, E. & Segal, B.H. 2021. Mechanisms driving neutrophil-induced T-cell immunoparalysis in ovarian cancer. Cancer Immunology Research 9(7): 790-810.

Fang, B., Mehran, R.J., Heymach, J.V. & Swisher, S.G. 2015. Predictive biomarkers in precision medicine and drug development against lung cancer. Chinese Journal of Cancer 34(3): 1-15.

Fang, S., Dai, Y., Mei, Y., Yang, M., Hu, L., Yang, H., Guan, X. & Li, J. 2019. Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers. Thoracic Cancer 10(2): 277-288.

Foretz, M., Pacot, C., Dugail, I., Lemarchand, P., Guichard, C., Le Lièpvre, X., Berthelier-Lubrano, C., Spiegelman, B., Kim, J.B., Ferré, P. & Foufelle, F. 1999. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Molecular and Cellular Biology 19(5): 3760-3768.

Gandara, D.R., Hammerman, P.S., Sos, M.L., Lara, P.N. & Hirsch, F.R. 2015. Squamous cell lung cancer: From tumor genomics to cancer therapeutics. Clinical Cancer Research 21(10): 2236-2243.

Ghosh, M., Dwyer-Nield, L.D., Kwon, J.B., Barthel, L., Janssen, W.J., Merrick, D.T. & Keith, R.L. 2015. Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer. PLoS ONE 10(4): e0122823.

Gong, N., Wu, R., Ding, B. & Wu, W. 2020. ERBB4 promotes the progression of inflammatory breast cancer through regulating PDGFRA. Translational Cancer Research 9(5): 3266.

Gonzalez, H., Hagerling, C. & Werb, Z. 2018. Roles of the immune system in cancer: From tumor initiation to metastatic progression. Genes & Development 32(19-20): 1267-1284.

González, L.A., Melo-González, F., Sebastián, V.P., Vallejos, O.P., Noguera, L.P., Suazo, I.D., Schultz, B.M., Manosalva, A.H., Peñaloza, H.F., Soto, J.A., Parker, D., Riedel, C.A., González, P.A., Kalergis, A.M. & Bueno, S.M. 2021. Characterization of the anti-inflammatory capacity of IL-10-producing neutrophils in response to Streptococcus pneumoniae infection. Frontiers in Immunology 12: 638917.

Gu, L., Saha, S.T., Thomas, J. & Kaur, M. 2019. Targeting cellular cholesterol for anticancer therapy. The FEBS Journal 286(21): 4192-4208.

Gu, W., Zhuang, W., Zhuang, M., He, M. & Li, Z. 2023. DNA damage response and repair gene mutations are associated with tumor mutational burden and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients. Diagnostic Pathology 18(1): 119.

Guenzi, E., Pluvy, J., Guyard, A., Nguenang, M., Rebah, K., Benrahmoune, Z., Lamoril, J., Cazes, A., Gounant, V., Brosseau, S., Boileau, C., Zalcman, G. & Théou-Anton, N. 2021. A new KIF5B–ERBB4 gene fusion in a lung adenocarcinoma patient. ERJ Open Research 7(1): 00582-2020.

Hamilton, J.A. & Achuthan, A. 2013. Colony stimulating factors and myeloid cell biology in health and disease. Trends in Immunology 34(2): 81-89.

Hartmann, P., Trufa, D.I., Hohenberger, K., Tausche, P., Trump, S., Mittler, S., Geppert, C.I., Rieker, R.J., Schieweck, O., Sirbu, H., Hartmann, A. & Finotto, S. 2023. Contribution of serum lipids and cholesterol cellular metabolism in lung cancer development and progression. Scientific Reports 13(1): 5662.

Henry, C.J., Billups, L.H., Avery, M.D., Rude, T.H., Dansie, D.R., Lopez, A., Sass, B., Whitmire, C.E. & Kouri, R.E. 1981. Lung cancer model system using 3-methylcholanthrene in inbred strains of mice. Cancer Research 41: 5027-5032.

Hoppstädter, J., Dembek, A., Höring, M., Schymik, H. S., Dahlem, C., Sultan, A., Wirth, N., Al-Fityan, S., Diesel, B., Gasparoni, G., Walter, J., Helms, V., Huwer, H., Simon, M., Liebisch, G., Schulz, M.H. & Kiemer, A.K. 2021. Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages. EBioMedicine 72: 103578.

 Hu, X., Xu, H., Xue, Q., Wen, R., Jiao, W. & Tian, K. 2021. The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors. Molecular Medicine 27: 126.

Huang, P., Nedelcu, D., Watanabe, M., Jao, C., Kim, Y., Liu, J. & Salic, A. 2016. Cellular cholesterol directly activates smoothened in hedgehog signaling. Cell 166(5): 1176-1187.

Hulsen, T., de Vlieg, J. & Alkema, W. 2008. BioVenn–A web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 9(1): 488.

Janiszewska, M., Primi, M.C. & Izard, T. 2020. Cell adhesion in cancer: Beyond the migration of single cells. Journal of Biological Chemistry 295(8): 2495-2505.

Jiang, S., Wang, X., Song, D., Liu, X., Gu, Y., Xu, Z., Wang, X., Zhang, X., Ye, Q., Tong, Z., Yan, B., Yu, J., Chen, Y., Sun, M., Wang, Y. & Gao, S. 2019. Cholesterol induces epithelial-to-mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP. Cancer Research 79(12): 3063-3075.

Kawano, M., Mabuchi, S., Matsumoto, Y., Sasano, T., Takahashi, R., Kuroda, H., Kozasa, K., Hashimoto, K., Isobe, A., Sawada, K., Hamasaki, T., Morii, E. & Kimura, T. 2015. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Scientific Reports 5(1): 18217.

Khoshnoodi, J., Sigmundsson, K., Öfverstedt, L-G., Skoglund, U., Öbrink, B., Wartiovaara, J. & Tryggvason, K. 2003. Nephrin promotes cell-cell adhesion through homophilic interactions. The American Journal of Pathology 163(6): 2337-2346.

Kim, S.H., Baek, S.I., Jung, J., Lee, E.S., Na, Y., Hwang, B.Y., Roh, Y.S., Hong, J.T., Han, S.B. & Kim, Y. 2022. Chemical inhibition of TRAF6-TAK1 axis as therapeutic strategy of endotoxin-induced liver disease. Biomedicine & Pharmacotherapy 155: 113688.

Kircher, M., Witten, D.M., Jain, P., O’roak, B.J., Cooper, G.M. & Shendure, J. 2014. A general framework for estimating the relative pathogenicity of human genetic variants. Nature Genetics 46(3): 310-315.

Korpanty, G.J., Graham, D.M., Vincent, M.D. & Leighl, N.B. 2014. Biomarkers that currently effect clinical practice in lung cancer: EGFR, ALK, MET, ROS-1 and KRAS. Frontiers in Oncology 4: 204.

Kourtidis, A., Lu, R., Pence, L.J. & Anastasiadis, P.Z. 2017. A central role for cadherin signaling in cancer. Experimental Cell Research 358(1): 78-85.

Kowanetz, M., Wu, X., Lee, J., Tan, M., Hagenbeek, T., Qu, X., Yu, L., Ross, J., Korsisaari, N., Cao, T., Bou-Reslan, H., Kallop, D., Weimer, R., Ludlam, M.J., Kaminker, J.S., Modrusan, Z., van Bruggen, N., Peale, F.V., Carano, R., Meng, Y.G. & Ferrara, N. 2010. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+ Ly6C+ granulocytes. Proceedings of the National Academy of Sciences 107(50): 21248-21255.

Kuzu, O.F., Gowda, R., Noory, M.A. & Robertson, G.P. 2017. Modulating cancer cell survival by targeting intracellular cholesterol transport. British Journal of Cancer 117(4): 513-524.

Lau, C., Killian, K.J., Samuels, Y. & Rudloff, U. 2014. ERBB4 mutation analysis: Emerging molecular target for melanoma treatment. Molecular Diagnostics for Melanoma: Methods and Protocols 1102: 461-480.

Lewis, C.A., Brault, C., Peck, B., Bensaad, K., Griffiths, B., Mitter, R., Chakravarty, P., East, P., Dankworth, B., Alibhai, D., Harris, A.L. & Schulze, A. 2015. SREBP maintains lipid biosynthesis and viability of cancer cells under lipid-and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene 34(40): 5128-5140.

Li, J., Liu, N., Tang, L., Yan, B., Chen, X., Zhang, J. & Peng, C. 2020. The relationship between TRAF6 and tumors. Cancer Cell International 20: 429.

Liang, S., Xu, Y., Tan, F., Ding, L., Ma, Y. & Wang, M. 2018. Efficacy of icotinib in advanced lung squamous cell carcinoma. Cancer Medicine 7(9): 4456-4466.

Liberzon, A., Subramanian, A., Pinchback, R., Thorvaldsdóttir, H., Tamayo, P. & Mesirov, J. P. 2011. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27(12): 1739-1740.

Liu, C.C., Lin, J.H., Hsu, T.W., Hsu, J.W., Chang, J.W., Su, K., Hsu, H.S. & Hung, S.C. 2018. Collagen XVII/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer. Oncotarget 9(2): 1656-1672.

Liu, L., Wu, Y., Zhang, C., Zhou, C., Li, Y., Zeng, Y., Zhang, C., Li, R., Luo, D., Wang, L., Zhang, L., Tu, S., Deng, H., Luo, S., Chen, Y.G., Xiong, X. & Yan, X. 2020. Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling. Journal of Molecular Cell Biology 12(9): 723-737.

Love, M.I., Huber, W. & Anders, S. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology 15(12): 550.

Lucas, L.M., Dwivedi, V., Senfeld, J.I., Cullum, R.L., Mill, C.P., Piazza, J.T., Bryant, I.N., Cook, L.J., Miller, S.T., Lott 4th, J.H., Kelley, C.M., Knerr, E.L., Markham, J.A., Kaufmann, D.P., Jacobi, M.A., Shen, J. & Riese 2nd, D.J. 2022. The yin and yang of ERBB4: tumor suppressor and oncoprotein. Pharmacological Reviews 74(1): 18-47.

Masroor, M., Javid, J., Mir, R., Mohan, A., Ray, P.C. & Saxena, A. 2016. Prognostic significance of serum ERBB 3 and ERBB 4 mRNA in lung adenocarcinoma patients. Tumor Biology 37: 857-863.

Mayfosh, A.J., Baschuk, N. & Hulett, M.D. 2019. Leukocyte heparanase: A double-edged sword in tumor progression. Frontiers in Oncology 9: 331.

McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M. & DePristo, M.A. 2010. The genome analysis toolkit: A mapreduce framework for analyzing next-generation DNA sequencing data. Genome Research 20(9): 1297-1303.

Missiaen, R., Mazzone, M. & Bergers, G. 2018. The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer. Seminars in Cancer Biology 52: 107-116.

Mok, E.H.K. & Lee, T.K.W. 2020. The pivotal role of the dysregulation of cholesterol homeostasis in cancer: Implications for therapeutic targets. Cancers 12(6): 1410.

Mollinedo, F. 2019. Neutrophil degranulation, plasticity, and cancer metastasis. Trends in Immunology 40(3): 228-242.

Mootha, V.K., Lindgren, C.M., Eriksson, K.F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., Houstis, N., Daly, M.J., Patterson, N., Mesirov, J.P., Golub, T.R., Tamayo, P., Spiegelman, B., Lander, E.S., Hirschhorn, J.N., Altshuler, D. & Groop, L.C. 2003. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics 34(3): 267-273. 

Morris, K.T., Khan, H., Ahmad, A., Weston, L.L., Nofchissey, R.A., Pinchuk, I.V. & Beswick, E.J. 2014. G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. British Journal of Cancer 110(5): 1211-1220.

Morris, K.T., Castillo, E.F., Ray, A.L., Weston, L.L., Nofchissey, R.A., Hanson, J.A., Samedi, V.G., Pinchuk, I.V., Hudson, L.G. & Beswick, E.J. 2015. Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting NK cell, macrophage and T cell responses. Oncotarget 6(26): 22338.

Natarajan, S., Foreman, K.M., Soriano, M.I., Rossen, N.S., Shehade, H., Fregoso, D.R., Eggold, J.T., Krishnan, V., Dorigo, O., Krieg, A.J., Heilshorn, S.C., Sinha, S., Fuh, K.C. & Rankin, E.B. 2019. Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis. Cancer Research 79(9): 2271-2284.

 Okazaki, T., Ebihara, S., Asada, M., Kanda, A., Sasaki, H. & Yamaya, M. 2006. Granulocyte colony-stimulating factor promotes tumor angiogenesis via increasing circulating endothelial progenitor cells and Gr1+ CD11b+ cells in cancer animal models. International Immunology 18(1): 1-9.

Pan, J., Xiong, D., Zhang, Q., Szabo, E., Miller, M.S., Lubet, R.A., Wang, Y. & You, M. 2018. Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma. Scientific Reports 8(1): 8895.

Raudvere, U., Kolberg, L., Kuzmin, I., Arak, T., Adler, P., Peterson, H. & Vilo, J. 2019. g: Profiler: A web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Research 47(W1): W191-W198.

Riolobos, L., Gad, E.A., Treuting, P.M., Timms, A.E., Hershberg, E.A., Corulli, L.R., Rodmaker, E. & Disis, M.L. 2019. The effect of mouse strain, sex, and carcinogen dose on toxicity and the development of lung dysplasia and squamous cell carcinomas in mice. Cancer Prevention Research 12(8): 507-516.

Rodriguez, J.M., Maietta, P., Ezkurdia, I., Pietrelli, A., Wesselink, J.J., Lopez, G., Valencia, A. & Tress, M.L. 2013. APPRIS: Annotation of principal and alternative splice isoforms. Nucleic Acids Research41(Database issue): D110-117.

Sang, S., Zhang, C. & Shan, J. 2019. Pyrroline-5-carboxylate reductase 1 accelerates the migration and invasion of nonsmall cell lung cancer in vitro. Cancer Biotherapy and Radiopharmaceuticals 34(6): 380-387.

She, Y., Mao, A., Li, F. & Wei, X. 2019. P5CR1 protein expression and the effect of gene-silencing on lung adenocarcinoma. PeerJ 7: e6934.

Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A.H., Osuga, J., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., Gotoda, T., Ishibashi, S. & Yamada, N. 1999. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. Journal of Biological Chemistry 274(50): 35832-35839.

Siegel, R.L., Giaquinto, A.N. & Jemal, A. 2024. Cancer statistics, 2024. CA: A Cancer Journal for Clinicians 74(1): 12-49.

Strell, C., Lang, K., Niggemann, B., Zaenker, K.S. & Entschladen, F. 2010. Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1. Experimental Cell Research 316(1): 138-148.

Subramanian, A., Tamayo, P., Mootha, V.K., Mukherjee, S., Ebert, B.L., Gillette, M.A., Paulovich, A., Pomeroy, S.L., Golub, T.R., Lander, E.S. & Mesirov, J.P. 2005. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences 102(43): 15545-15550.

Sun, F., Yang, X., Jin, Y., Chen, L., Wang, L., Shi, M., Zhan, C., Shi, Y. & Wang, Q. 2017. Bioinformatics analyses of the differences between lung adenocarcinoma and squamous cell carcinoma using The Cancer Genome Atlas expression data. Molecular Medicine Reports 16(1): 609-616.

Surien, O., Ghazali, A.R. & Masre, S.F. 2020. Histopathological effect of pterostilbene as chemoprevention in N-nitroso-tri-chloroethylurea (NTCU)-Induced lung squamous cell carcinoma (SCC) mouse model. Histology and Histopathology 35(10): 1159-1170.

Suzuki, A., Onodera, K., Matsui, K., Seki, M., Esumi, H., Soga, T., Sugano, S., Kohno, T., Suzuki, Y. & Tsuchihara, K. 2019. Characterization of cancer omics and drug perturbations in panels of lung cancer cells. Scientific Reports 9(1): 19529.

Taghehchian, N., Moghbeli, M., Mashkani, B. & Abbaszadegan, M.R. 2021. The level of mesenchymal-epithelial transition autophosphorylation is correlated with esophageal squamous cell carcinoma migration. Iranian Biomedical Journal 25(4): 243.

Tamiya, M., Kobayashi, M., Morimura, O., Yasue, T., Nakasuji, T., Satomu, M., Kohei, O., Takayuki, S., Morishita, N., Suzuki, H., Sasada, S., Okamoto, N., Hirashima, T. & Kawase, I. 2013. Clinical significance of the serum crosslinked N-telopeptide of type i collagen as a prognostic marker for non-small-cell lung cancer. Clinical Lung Cancer 14(1): 50-54.

Tan, A.C. & Tan, D.S.W. 2022. Targeted therapies for lung cancer patients with oncogenic driver molecular alterations. Journal of Clinical Oncology 40(6): 611-625.

Tsai, J.H. & Yang, J. 2013. Epithelial–mesenchymal plasticity in carcinoma metastasis. Genes & Development 27(20): 2192-2206.

Valencia, K., Sainz, C., Bértolo, C., de Biurrun, G., Agorreta, J., Azpilikueta, A., Larrayoz, M., Bosco, G., Zandueta, C., Redrado, M., Redín, E., Exposito, F., Serrano, D., Echepare, M., Ajona, D., Melero, I., Pio, R., Thomas, R., Calvo, A. & Montuenga, L.M. 2022. Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma. Disease Models & Mechanisms 15(1): dmm049137.

Verstrepen, L., Bekaert, T., Chau, T.L., Tavernier, J., Chariot, A. & Beyaert, R. 2008. TLR-4, IL-1R and TNF-R signaling to NF-κB: Variations on a common theme. Cellular and Molecular Life Sciences 65: 2964-2978.

Voiles, L., Lewis, D.E., Han, L., Lupov, I.P., Lin, T.L., Robertson, M.J., Petrache, I. & Chang, H.C. 2014. Overexpression of type VI collagen in neoplastic lung tissues. Oncology Reports 32(5): 1897-1904.

Wang, B.Y., Huang, J.Y., Chen, H.C., Lin, C.H., Lin, S.H., Hung, W.H. & Cheng, Y.F. 2020. The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients. Journal of Cancer Research and Clinical Oncology 146(3): 43-52.

Wang, D., Wang, L., Zhang, Y., Yan, Z., Liu, L. & Chen, G. 2019. PYCR1 promotes the progression of non-small-cell lung cancer under the negative regulation of miR-488. Biomedicine & Pharmacotherapy 111: 588-595.

Wang, Q.L. & Liu, L. 2019. PYCR1 is associated with papillary renal cell carcinoma progression. Open Medicine 14(1): 586-592.

Wang, Y., Zhang, Z., Garbow, J.R., Rowland, D.J., Lubet, R.A., Sit, D., Law, F. & You, M. 2009. Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. Cancer Prevention Research 2(7): 634-640.

Wang, Y., Zhang, Z., Yan, Y., Lemon, W.J., Laregina, M., Morrison, C. & Lubet, R. 2004. A chemically induced model for squamous cell carcinoma of the lung in mice : Histopathology and strain susceptibility. Cancer Research 64(5): 1647-1654.

Weijin, F., Zhibin, X., Shengfeng, Z., Xiaoli, Y., Qijian, D., Jiayi, L., Qiumei, L., Yilong, C., Hua, M., Deyun, L. & Jiwen, C. 2019. The clinical significance of PYCR1 expression in renal cell carcinoma. Medicine 98(28): e16384.

Williams, C.S., Bernard, J.K., Demory Beckler, M., Almohazey, D., Washington, M.K., Smith, J.J. & Frey, M.R. 2015. ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis 36(7): 710-718.

Xiong, D., Pan, J., Yin, Y., Jiang, H., Szabo, E., Lubet, R.A., Wang, Y. & You, M. 2018. Novel mutational landscapes and expression signatures of lung squamous cell carcinoma. Oncotarget 9(7): 7424-7441.

Xu, S., Xu, H., Wang, W., Li, S., Li, H., Li, T., Zhang, W., Yu, X. & Liu, L. 2019. The role of collagen in cancer: From bench to bedside. Journal of Translational Medicine 17(1): 309.

Yamano, S., Gi, M., Tago, Y., Doi, K., Okada, S., Hirayama, Y., Tachibana, H., Ishii, N., Fujioka, M., Tatsumi, K. & Wanibuchi, H. 2016. Role of deltaNp63posCD44vpos cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. Cancer Science 107(2): 123-132. doi:10.1111/cas.12855

Yi, M., Dong, Y., Zheng, M., Barr, M.P., Roviello, G., Zhihuang, H. & Liu, J. 2024. Identification of a prognostic gene signature in patients with cisplatin resistant squamous cell lung cancer. Journal of Thoracic Disease 16: 4567-4583.

Yoshimoto, T., Inoue, T., Iizuka, H., Nishikawa, H., Sakatani, M., Ogura, T., Hirao, F. & Yamamura, Y. 1980. Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. Cancer Research 40(11): 4301-4307.

Yoshimoto, T., Hirao, F., Sakatani, M., Nishikawa, H., Ogura, T. & Yamamura, Y. 1977. Induction of squamous cell carcinoma in the lung of C57BL/6 mice by intratracheal instillation of benzo [a] pyrene with charcoal powder. GANN Japanese Journal of Cancer Research 68(3): 343-352.

Yu, J.M., Sun, W., Hua, F., Xie, J., Lin, H., Zhou, D.D. & Hu, Z.W. 2015. BCL6 induces EMT by promoting the ZEB1-mediated transcription repression of E-cadherin in breast cancer cells. Cancer Letters 365(2): 190-200.

Zakaria, M.A., Aziz, J., Rajab, N.F., Chua, E.W. & Masre, S.F. 2022. Tissue rigidity increased during carcinogenesis of NTCU-induced lung squamous cell carcinoma in vivo. Biomedicines 10(10): 2382.

Zakaria, M.A., Rajab, N.F., Chua, E.W., Selvarajah, G.T. & Masre, S.F. 2021a. NTCU induced pre-malignant and malignant stages of lung squamous cell carcinoma in mice model. Scientific Reports 11(1): 22500.

Zakaria, M.A., Rajab, N.F., Chua, E.W., Selvarajah, G.T. & Masre, S.F. 2021b. Roles of Rho‑associated kinase in lung cancer. International Journal of Oncology 58(2): 185-198.

Zeng, T., Zhu, L., Liao, M., Zhuo, W., Yang, S., Wu, W. & Wang, D. 2017. Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer. Medical Oncology 34(2): 27.

Zhang, X.C., Wang, J., Shao, G.G., Wang, Q., Qu, X., Wang, B., Moy, C., Fan, Y., Albertyn, Z., Huang, X., Zhang, J., Qiu, Y., Platero, S., Lorenzi, M.V., Zudaire, E., Yang, J., Cheng, Y., Xu, L. & Wu, Y.L. 2019. Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients. Nature Communications 10(1): 1772. 

Zhang, Z., Wang, Y., Chen, L. & Li, Z. 2019. Protective effects of the suppressed NF‐κB/TLR4 signaling pathway on oxidative stress of lung tissue in rat with acute lung injury. The Kaohsiung Journal of Medical Sciences 35(5): 265-276.

Zhao, W., Choi, Y. La, Song, J. Y., Zhu, Y., Xu, Q., Zhang, F., Jiang, L., Cheng, J., Zheng, G. & Mao, M. 2016. ALK, ROS1 and RET rearrangements in lung squamous cell carcinoma are very rare. Lung Cancer 94: 22-27.

Zilionis, R., Engblom, C., Pfirschke, C., Savova, V., Zemmour, D., Saatcioglu, H.D., Krishnan, I., Maroni, G., Meyerovitz, C.V., Kerwin, C.M., Choi, S., Richards, W.G., De Rienzo, A., Tenen, D.G., Bueno, R., Levantini, E., Pittet, M.J. & Klein, A.M. 2019. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity 50(5): 1317-1334.e.10.

 

*Pengarang untuk surat-menyurat; email: sitifathiah@ukm.edu.my